BRAF and NRAS mutational status are prognostically important in thick and locally advanced cutaneous melanoma

Title: BRAF and NRAS mutational status are prognostically important in thick and locally advanced cutaneous melanoma
Creator: Vilain, R.; Braye, S. G.; Ashman, L.; Scott, R. J.
Relation: 2011 International Melanoma Congress. Pigment Cell & Melanoma Research (Tampa, FL 9-13 November, 2011) p. 1051
Publisher Link: http://dx.doi.org/10.1111/j.1755-148X.2011.00909.x
Publisher: Wiley-Blackwell Publishing
Resource Type: conference paper
Date: 2011
Description: In this study, we have genotyped 192 cases of thick and/or metastatic melanoma, arising in a population exposed to a high degree of ambient UV radiation, and analysed the mutations in relation to the degree of cutaneous sun damage, and to clinical outcome. We report BRAF and NRAS mutations are, respectively, associated with impaired and enhanced survival outcomes. Furthermore, this effect is mediated by a differential metastatic rate to locoregional sites, and subsequently upon distant sites.
Subject: metastatic; melanoma; UV radiation; mutations
Identifier: http://hdl.handle.net/1959.13/1036337
Identifier: uon:13259
Identifier: ISSN:1755-148X
Language: eng

		Thumbnail	File	Description	Size	Format